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Pulmonary Vascular Disease: Pulmonary Hypertension |

Psychometric Validation of the PAH Symptoms and Impact (PAH-SYMPACT) Questionnaire: Results From the SYMPHONY Study

Robert Frantz, MD; Richard Channick, MD; Kelly Chin, MD; Aryeh Fischer, MD; Mardi Gomberg-Maitland, MD; Leah Kleinman, DrPH; Chad Miller, MD; Elke Hunsche, PhD; Roham Zamanian, MD; Michael Zastrow, PhD; David Badesch, MD
Author and Funding Information

Mayo Clinic, Rochester, MN


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):1160A. doi:10.1016/j.chest.2016.08.1269
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SESSION TITLE: Pulmonary Hypertension

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Monday, October 24, 2016 at 04:30 PM - 05:30 PM

PURPOSE: The PAH-SYMPACT is a patient reported outcome (PRO) instrument developed based on interviews with PAH patients and following the process outlined in the FDA's PRO guidance. Its psychometric characteristics are being evaluated using data from SYMPHONY - a phase IIIb PAH study with macitentan. After item reduction, the final instrument consists of 11 symptom and 11 impact items across 4 domains (cardiopulmonary symptoms [CP], cardiovascular symptoms [CV], physical impact and cognitive/emotional impacts). The objective of the current analyses was to evaluate the psychometric properties of the PAH-SYMPACT domain scores.

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