Pulmonary Vascular Disease: Cystic Fibrosis |

Clinical Utility of Sputum Cultures During Cystic Fibrosis Exacerbation Requiring Hospital Admission FREE TO VIEW

Matthew McLaughlin, DO; Enrique Calvo-Ayala, MD
Author and Funding Information

Eastern Virginia Medical School, Norfolk, VA

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):1134A. doi:10.1016/j.chest.2016.08.1244
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SESSION TITLE: Cystic Fibrosis

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: To determine if there are differences in the number and sensitivity of pathogens isolated from sputum culture performed at a cystic fibrosis (CF) accredited lab compared to a standard sputum culture in subjects with CF exacerbation requiring hospital admission.

METHODS: Design: Restrospective chart review. Subjects: Patients age 18-89 admitted with CF pulmonary exacerbation who had samples for both a CF sputum culture and standard sputum culture within 24 hours were analyzed.

RESULTS: Seventeen pairs of sputum cultures were identified. Included subjects had a mean age of 30 (range 21-65), 58.8% of subjects were female. 11/17 culture pairs had discordant pathogens. As expected, CF culture isolated more pathogens including additional Pseudomonas isolates (10/17 pairs). In 3/17 pairs, the standard sputum culture isolated pathogens not found on the CF culture. When comparing results of antibiotic sensitivities in cultures that isolated Pseudomonas (9 pairs of cultures), 7/9 of cultures sets disclosed discordant susceptibilities. 59% of the regular cultures either identified an additional pathogen or gave a different antibiotic sensitivity as compared to CF culture.

CONCLUSIONS: In our population, there was a high discordance rate between CF sputum culture and standard sputum culture. Often, the discordance was due to additional pathogens growing in the CF sputum culture. However, there were 10 cultures (59%) where standard respiratory culture either grew out a pathogen not seen on CF culture or disclosed a different resistance pattern of the isolated Pseudomonas.

CLINICAL IMPLICATIONS: Respiratory cultures performed in subjects with CF pulmonary exacerbations may not be useful to guide the antimicrobial therapy of these patients as the identification of pathogens and the disclosed sensitivity pattern varies.

DISCLOSURE: The following authors have nothing to disclose: Matthew McLaughlin, Enrique Calvo-Ayala

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