PURPOSE: In the patients with bronchiectasis, it is of great importance to remove the secretions in controlling the symptoms, preventing exacerbations, maintaining airway patency, and improving quality of life. Postural drainage is the best known non-pharmacological conventional therapy. Additionally, the active cycle of breathing techniques (ACPRC) are also used for this purpose. VEST™ device generating high-frequency chest wall compression is also used for mobilization of mucus secretions in the patients with bronchiectasis. The present study aimed to investigate efficiency of VEST™ application added to postural drainage. Primary end-point was amount of sputum discharge and the secondary end-points were quality of life, dyspnea score, CRP level, and hypoxia.