Pulmonary Physiology: Pulmonary Physiology |

Impulse Oscillometry Compared to Spirometry in Adults With a History of Bronchitis FREE TO VIEW

Ali Asseri, MD; Debra Stern; Stefano Guerra; Anne Wright; Fernando Martinez; Wayne Morgan
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University of Arizona, Tucson, AZ

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):1113A. doi:10.1016/j.chest.2016.08.1221
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SESSION TITLE: Pulmonary Physiology

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: Impulse Oscillometry (IOS) is an effort independent tool to assess respiratory mechanics. However, there is little evidence to support the use of IOS as a screening tool for the early stages of pulmonary diseases that originate at the level of small airway. We aimed in this study to compare IOS and spirometry for the ability to detect airway dysfunction in participants who reported a history of bronchitis.

METHODS: Participants were enrolled in the Tucson Children’s Respiratory Study, a non-selected birth cohort. Questionnaires were completed at age 32 years. Bronchitis was defined as at least one episode of self-reported bronchitis during the previous year. IOS and spirometry were completed at age 32 years according to ATS/ERS standards when the participant had been well for at least one month. IOS and spirometry parameters were regressed on height, weight, gender and ethnicity and the standardized residuals were used as the outcome measure. Standardized residuals of IOS and spirometry measures were tested for association with bronchitis in the prior year by Student’s unpaired t test.

RESULTS: Analyses were limited to 130 participants with data on bronchitis, spirometry and IOS measures at age 32 years. The prevalence of bronchitis was 10% (13/130) and 9 of the 13 participants who reported bronchitis consulted a physician for their illness. Participants with bronchitis had significantly increased resistance at 5, 10, and 15Hz by 0.83 (p=0.004), 0.73 (p=0.01), and 0.65 (p=0.03) standard deviations, respectively, and decreased reactance at 5Hz by -0.75 (p=0.01) standard deviations compared to healthy participants. Area of reactance and resonant frequency were significantly increased for participants with a history of bronchitis compared to healthy participants (0.68 (p=0.02) and 0.61 (p=0.04) standard deviation, respectively). These associations were independent of current smoking and asthma. Spirometry measures did not show any statistically significant relation to bronchitis (all p >0.05).

CONCLUSIONS: IOS measures are able to identify early airway dysfunction in participants with a history of bronchitis in the prior year, which was not detected by spirometry. This demonstrates the ability of IOS to detect early manifestations of pulmonary dysfunction prior to alterations in forced expiratory flow.

CLINICAL IMPLICATIONS: Despite the infrequent use of oscillometry in clinical practice, this tool shows promise in detecting early signs of pulmonary disease compared to spirometry.

DISCLOSURE: Ali Asseri: Grant monies (from sources other than industry): NIH grant HL 56177 Debra Stern: Grant monies (from sources other than industry): NIH grant HL 56177 Stefano Guerra: Grant monies (from sources other than industry): NIH grant HL 56177 Anne Wright: Grant monies (from sources other than industry): NIH grant HL 56177 Fernando Martinez: Grant monies (from sources other than industry): NIH grant HL 56177 Wayne Morgan: Grant monies (from sources other than industry): NIH grant HL 56177

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