RESULTS: 23 patients with an established diagnosis of GPA underwent a total of 103 bronchoscopies. Female: Male ratio was 3:1, with a mean age of 41 years. 83% of patients were on immunosuppressive therapy at the time of bronchoscopy. The majority of patients were symptomatic (77%) with dyspnea (74%), cough (65%) and wheezing (37%) being the most common symptoms at presentation. On bronchoscopic examination, airway disease was identified in all patients, most commonly at the level of the subglottis (64%), trachea (51%) and distal airways (75%), while disease of the vocal cords was rarely seen (7%). The most common types of airway abnormalities included multifocal tracheobronchial stenosis (75%), subglottic stenosis (59%) and localized strictures (31%). Mucosal abnormalities such as edema, ulcerations and cobble stoning were seen in 36% of airway examinations. Other rare disease manifestations such as synechial membranes, pseudopolyps and submucosal tunnels were also observed. Additionally, thick crusty secretions were a common finding (39%). Endobronchial biopsies, when performed, showed no evidence of vasculitis. Notably, various bronchosopic interventions were effective at treating airway obstruction due to GPA. Balloon dilation was most commonly used (67%), along with steroid injections (63%) and application of mitomycin (39%). Other techniques included: rigid dilations (10%), electrosurgery (28%), cryotherapy (28%) and stent placement (14%). Improvement of airway disease was seen on 65% of repeat bronchoscopies. Moreover, symptoms improved in 89% of patients post intervention. No procedural complications or deaths were reported.