RESULTS: A total of 109 patients underwent EBUS-TBNA for 184 lesions. EBUS-TBNA provided diagnostic materials in 91 patients (83%; noncaseating epithelioid cell granuloma in 82, others in 9 patients). Finally, ninety-three patients were given a diagnosis of sarcoidosis; thus, the sensitivity of EBUS-TBNA for pathological diagnosis of sarcoidosis was 88% (82 of 93 patients). In the 82 patients with noncaseating epithelioid cell granulomas, eighty-one patients were given diagnostic materials from the main target lesion through 6 passes, and the remaining patient was given diagnostic materials only from the second target lesion. The cumulative yields through the first, second, third, fourth, fifth and sixth passes for the main target lesion were 71, 84, 91, 95, 96 and 99%, respectively. In the 56 patients who underwent EBUS-TBNA for multiple lesions, the cumulative yield of 2 passes per lesion for 2 lesions (total 4 passes) and 4 passes for single lesion was 96% and 93%, respectively (p = 0.40). No complications were associated with the procedures.