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Procedures: Procedures 1 - EMN/BT/Rigid/Cryo |

Bronchial Thermoplasty vs Omalizumab for Severe Uncontrolled Asthma: Relative Efficacy and Chronicity of Costs of Care

Michael Wechsler, MD; Michael Cangelosi, MPH; Michael Simmonds; Narinder Shargill, PhD; Dominic Tilden, MPH; Suzi Cottrell, PhD; Robert Niven, MD
Author and Funding Information

National Jewish Health, Denver, CO


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):1011A. doi:10.1016/j.chest.2016.08.1117
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Extract

SESSION TITLE: Procedures 1 - EMN/BT/Rigid/Cryo

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: Bronchial Thermoplasty (BT) is a one-time treatment recommended as a GINA Step 5 add-on treatment for severe uncontrolled asthma. Omalizumab (OM) is similarly recommended as a GINA Step 5 add-on treatment for uncontrolled asthma and these two treatments may be evaluated by clinicians as alternatives to one another. In the midst of discussions within the US regarding high drug costs for monoclonal antibody therapies, clinicians may consider the acute costs of a procedural treatment a reasonable alternative. However, no clinical trials have directly compared BT and OM to afford clinicians the ability to compare relative clinical efficacy as well as costs. Thus, an indirect treatment comparison (ITC) is presented using optimized asthma therapy (OAT) as a common control. ITCs are often utilised in health technology assessment to establish comparative effectiveness in the absence of direct trial evidence. We extend these results with a three year simulation of costs of care delivered and differences in asthma-related healthcare utilization.

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