RESULTS: 57 patients underwent ENB for workup of a pulmonary nodule or mass. Two patients had ENB performed for fiducial marker placement, and one for dye marking of a nodule prior to surgery. 61% of biopsies involved nodules in the upper lobes. 65% (n=26) of the nodules were between one and three centimeters in size. The overall diagnostic yield of ENB using radial EBUS and fluoroscopy was 68.4%. ENB with TBNA confirmed malignancy in 46% (n=26) of the total patients. Four individual cases of non-malignant etiologies were also confirmed by TBNA. Of the 54% (n=31) of cases which were negative by ENB, 38.7% (n=12) were confirmed to be malignant by subsequent CT guided or surgical biopsy. Two patients died and five were lost to follow up. The overall sensitivity of ENB was 68.4%, with a NPV of 47.8%. After looking at the location of the nodule, ENB had a 70.8% sensitivity and a 46.1% NPV for upper lobe lesions, and a 62.5% sensitivity and 33.3% NPV for lower lobe lesions. The first 30 patients undergoing ENB had a diagnostic sensitivity of 57.7%, which increased to 81.3% for the next 30 patients (p=0.05821). One patient was diagnosed with pneumothorax post procedure which resolved with conservative treatment.