CASE PRESENTATION: A 65 year old female with past medical history of COPD and Sjogren’s syndrome was found to have 1.6 cm right lower lobe and 1.4 cm left upper lobe irregular nodules as an incidental CT scan finding after a traumatic injury to her chest.Her review of systems was significant for dry mouth and non productive cough. A PET scan obtained as a follow up showed moderate FDG uptake with SUV of 4.0 and 2.3 respectively. Due to intermediate risks with a history of smoking and family history of breast cancer , tissue specimen via transbronchial biopsy were obtained to rule out cancer . Histology showed amorphous tissue material that stained positive for Congo red consistent with diagnosis of amyloidosis. She subsequently opted to have the right lower lobe nodule resected via a VATS procedure that conformed the diagnosis of amyloidosis.