RESULTS: 178 children, mean aged 8.6 year-old, were diagnosed with influenza. Male predominance (102 boys and 76 girls) was noticed. No one child was previously vaccinated against flu. The peak of B influenza illness was most pronounced in February 2015 and the peak of A type was greater in March in both years 2015 and 2016. The clinical patterns included acute febrile onset with variable degrees of illness severity, ranging from mild astenia to pneumonia and respiratory failure. Only 20 children (11.2%) had meningism or miositis. For the diagnosis and evaluation of the type of influenza (A or B) viral culture of nasopharyngeal and/or throat samples and Reverse Transcription-Polymerase Chain Reaction (RT-PCR) assay were performed in children. 71 cases (39.8%) were diagnosed with A H1N1 infection and 101 with B influenza infection (56.7%). Pneumonia was the most frequent complication of influenza (n=91/178; 56.1%) and it was highly reported in A H1N1 cases versus B type (54/71; 76 % versus 37/101; 36.6%; RR = 2.076 (1.557- 2.768); OR = 5.494 (2.787-10.83); Mantel- Haenszel chi square = 25.85; p = 0.0000001). Therapy with oseltamivir (150 mg twice daily) and added antibiotics improved the outcome in all children with pneumonia. No death was reported.