SESSION TITLE: Pediatric Pulmonary
SESSION TYPE: Original Investigation Slide
PRESENTED ON: Tuesday, October 25, 2016 at 02:45 PM - 04:15 PM
PURPOSE: Introduction: Respiratory Syncytial Virus (RSV) infection is the leading cause of hospital admission in children. Despite the global burden of RSV disease, management remains supportive. We have previously identified dysregulated protease activity, in particular, matrix metalloproteinase (MMP)-9 in children with RSV-induced respiratory failure. In children who were intubated and receiving mechanical ventilation, high levels of MMP-9 correlated with worse clinical measures of disease severity. The purpose of our study is to test the hypothesis that high levels of MMP-9 activity is measured early in the course of RSV infection, prior to the onset of respiratory failure (necessitating mechanical ventilation) and is predictive of disease severity.