Occupational and Environmental Lung Diseases: Occupational and Environmental Lung Disease |

Blood Cadmium and Medical Utilization With Bronchodilator Among Korean Patients With Mild to Moderate Lung Function Impairment FREE TO VIEW

Jun-Pyo Myong, PhD
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Seoul St. Mary's Hospital, Seoul, Korea (the Republic of)

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):932A. doi:10.1016/j.chest.2016.08.1033
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SESSION TITLE: Occupational and Environmental Lung Disease

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: The clinical symptoms of chronic lung diseases vary even in the similar lung volumes. The approach with phenotype of chronic obstructive lung diseases (COPD) might explain those phenomenon, however not enough. Cadmium can result in a decrease of the lung function decrease among general population. However, there is few study to evaluate a relationship between the cadmium levels and medical utilization such as bronchodilators. Therefore, the aim of the present study is to estimate the relationship as well as dose-relationship between blood cadmium levels and medical utilization with bronchodilator.

METHODS: After excluding the previous medical history due to COPD and asthma, Subjects with blood cadmium levels and mild-to moderate lung function impairment (FEV1/FVC < 0.7 and FEV1> 50%) from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2012. The medical records were obtained by prospectively linking to the National Health Insurance (NHI) reimbursement data. A retrospective cohort study was performed with 552 eligible population.

RESULTS: The median (ranges) and mean observed year were 1445.78 years, 2.65 years (0.05 (Min)- 4.99(Max)), and 2.62 years. The relative risks of highest cadmium quartiles (reference: lowest quartiles) were 11.625 (95% CIs:1.377 - 98.18) and 5.008 (95% CIs:1.042 - 24.073) among those with pulmonary function with “50 < %FEV1 ≤ 70” and “70 < %FEV1 ≤ 90”, respectively. After adjustment of age, gender, residence, household income, education, smoking, and drinking status, a dose-response relationship between the medical utilization with medication and blood cadmium levels was showed (p for trend < 0.05) among those with pulmonary function with “50 < %FEV1 ≤ 70” and “70 < %FEV1 ≤ 90”.

CONCLUSIONS: A dose-response relationship between the medical utilization with medication and blood cadmium levels were shown in the Korean general population with mild-to moderate lung function impairment.

CLINICAL IMPLICATIONS: An effort to reduce an environmental and occupational exposure to cadmium is necessary for vulnerable population such as lung function impairment.

DISCLOSURE: The following authors have nothing to disclose: Jun-Pyo Myong

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