RESULTS: 400 COPD patients (68.5% male) with a mean age 61.5±9 years (range, 40-70 years), of which 35.5% were current smokers, and 35% were ex-smokers were included. Patients presented at least one comorbidity, and The most frequent co-morbidities were cardiovascular diseases (84.5%), diabetes (34.5%), dyslipidaemia (23%), osteopenia & osteoporosis (16.5%), anemia (10%), muscle wasting (9%), pneumonia (6.5%), gastroesophageal reflux (1.5%) and lung cancer (1.5%). Association with cardiovascular events, dyslipidaemia, diabetes mellitus, osteoporosis, muscle wasting & anemia was highly significant in COPD patients ≥60 years, men &stage III & IV. Also Significant relation with CRP was found (p=0.0001). Lung cancer was found only in male COPD patient. The impact on depressive disorders was noted only in younger COPD men (p=0.001). Frequent exacerbators presented an increased risk of having two or more co-morbidities (Odds Ratio of 2), (p = 0.04) and more hospitalizations in the last year, (p < 0,01).