Obstructive Lung Diseases: Novel Predictors of COPD Outcomes |

Comorbidities in Patients With COPD FREE TO VIEW

Hamdy Mohammadien, MD; Mona Hussein, MD; Olaa Ahmad, MD
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Sohag Faculty of Medicine, Sohag University, Sohag, Egypt

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):914A. doi:10.1016/j.chest.2016.08.1014
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SESSION TITLE: Novel Predictors of COPD Outcomes

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, October 23, 2016 at 01:30 PM - 03:00 PM

PURPOSE: Comorbidities are common and significant in COPD, often contributing to symptoms, exacerbations, hospital admissions and mortality. Objective:To estimate the presence of comorbidities in patients with COPD and to assess the relationship of comorbid diseases with age, sex, CRP & COPD severity.

METHODS: The study included 400 COPD patients. COPD diagnosis was defined by GOLD criteria (FEV1/FVC < .70 post-bronchodilator). Information was collected on the following comorbidities: heart diseases, hypertension, diabetes mellitus, dyslipemia, anemia,osteopenia &osteoporosis, muscle weakness,pneumonia, lung cancer, gastroesophageal reflux and psychological conditions .

RESULTS: 400 COPD patients (68.5% male) with a mean age 61.5±9 years (range, 40-70 years), of which 35.5% were current smokers, and 35% were ex-smokers were included. Patients presented at least one comorbidity, and The most frequent co-morbidities were cardiovascular diseases (84.5%), diabetes (34.5%), dyslipidaemia (23%), osteopenia & osteoporosis (16.5%), anemia (10%), muscle wasting (9%), pneumonia (6.5%), gastroesophageal reflux (1.5%) and lung cancer (1.5%). Association with cardiovascular events, dyslipidaemia, diabetes mellitus, osteoporosis, muscle wasting & anemia was highly significant in COPD patients ≥60 years, men &stage III & IV. Also Significant relation with CRP was found (p=0.0001). Lung cancer was found only in male COPD patient. The impact on depressive disorders was noted only in younger COPD men (p=0.001). Frequent exacerbators presented an increased risk of having two or more co-morbidities (Odds Ratio of 2), (p = 0.04) and more hospitalizations in the last year, (p < 0,01).

CONCLUSIONS: Comorbidities are common in patients with COPD, and have a significant impact on health status and prognosis, thus justifying the need for a comprehensive and integrating therapeutic approach. Cardiovascular, diabetes mellitus, dyslipidaemia, musculoskeletal and psychological conditions are among the most prevalent and important of these.

CLINICAL IMPLICATIONS: Extrapulmonary comorbidities are common and significant in chronic obstructive pulmonary disease (COPD), often contributing to symptoms, exacerbations, hospital admissions and mortality so that in the management of COPD all these conditions need to be carefully evaluated and treated .

DISCLOSURE: The following authors have nothing to disclose: Hamdy Mohammadien, Mona Hussein, Olaa Ahmad

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