RESULTS: A total 250 patients were enrolled. The mean age ± SD was 64.59± 8.45 years. The total in-hospital mortality was 17.2% and the need for MV was 54.4%. The risk of clinical deterioration (need of MV and/or mortality) increased exponentially with increasing scores. All recorded scores were significantly higher in non-survivors compared with survivors. The discriminatory power of these scores was variable; AUC of APACHE-II, SOFA, EWS, GCS, CCI and ACCI Index were 0.79, 0.81, 0.76, 0.69, 0.68 and 0.73, respectively and all these models had good calibration in mortality prediction. Meanwhile, in predicting the need of intubation and MV in AECOPD, the discrimination power by AUC of 0.79, 0.80, 0.73, 0.81 and 0.61, 0.62, respectively. Calibration was acceptable for all scores except for SOFA, which had poor calibration.