0
Obstructive Lung Diseases: COPD |

COPD-Related Hospitalizations Associated With Arformoterol Tartrate (ARF) Treatment Among Patients Receiving Concomitant Tiotropium (TIO) Therapy: Post Hoc Analyses From a 52-Week Randomized, Controlled Study

James Donohue, MD; Vaidyanathan Ganapathy; Eric Davenport, MS; Lauren Nelson, PhD; Xiaolei Zhou, PhD
Author and Funding Information

Department of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):890A. doi:10.1016/j.chest.2016.08.990
Text Size: A A A
Published online

Extract

SESSION TITLE: COPD

SESSION TYPE: Original Investigation Poster Discussion

PRESENTED ON: Monday, October 24, 2016 at 12:00 PM - 01:30 PM

PURPOSE: To evaluate treatment differences between nebulized ARF and placebo (PBO) with/without concomitant TIO on the risk of COPD-related hospitalizations.

METHODS: Data used in this analysis came from a multicenter, randomized, double-blind, simple safety, 52-week trial of nebulized ARF or PBO. Use of TIO was permitted. Inclusion criteria were COPD diagnosis with a forced expiratory volume/second (FEV1) ≤50% of predicted, FEV1/forced vital capacity ratio ≤70%, age ≥40 years, smoking history ≥15 pack years, and breathlessness severity grade ≥2. Key study outcomes included COPD exacerbation-related hospitalizations, and health-related quality of life assessed by St. George’s Respiratory Questionnaire (SGRQ). Poisson regression was used to estimate treatment differences in annualized COPD exacerbation-related hospitalization rates while patients were on treatment, adjusting for baseline smoking status, COPD severity, age, and exacerbation category (0, 1, or ≥2 exacerbations in the past year). Treatment differences in hospitalizations were also assessed in SGRQ responders (improvement in SGRQ total score by 4 points from baseline to month 12).

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543