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Obstructive Lung Diseases: Airways 5 |

Metabolomics in COPD Acute Respiratory Failure

Spyridon Fortis, MD; Elizabeth Lusczek; Craig Weinert, MD; Gregory Beilman, MD
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University of Minnesota, Minneapolis, MN


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):885A. doi:10.1016/j.chest.2016.08.985
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SESSION TITLE: Airways 5

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: Acute respiratory failure (ARF) due to COPD exacerbation causes distressing symptoms of severe dyspnea, is costly and decreases patients’ functional status long after hospital discharge. Severe airflow obstruction increases respiratory muscle workload and can lead to respiratory muscle fatigue, a cardinal feature of ARF. Biochemical changes associated with respiratory muscle fatigue and the high metabolic demand state in COPD with ARF have not well been studied. Early treatment of COPD exacerbations reduces hospitalization and improves health-related quality of life. Therefore, early diagnosis of COPD exacerbation when symptoms are mild or absent is critical. Since there are no objective biomarkers for COPD exacerbation, its diagnosis is based solely on clinical findings which may result in overtreatment. Many human diseases including COPD are associated with an abnormal metabolic state. Serum metabolic profiles correlate with severity of cachexia and obstruction in COPD. However, it is not known whether the transition from stable COPD to an exacerbation severe enough to require non-invasive positive pressure mechanical ventilation (NIPPV) is correlated with changes in the metabolic profile. Hypothesis: ARF in patients with COPD that require NIPPV is characterized by a unique metabolic profile in body fluids.

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