RESULTS: Of the 26 subjects included into the study, majority (77%) were females. The mean age was 69±12 years. Ethnicity distribution is as follows: Caucasian 65%, Hispanics 19%, & African Americans 11%. The median BMI was 26.175 [20.57, 34.1] kg/m2 with 50% obese, out of which 8% were morbidly obese. All of the patients were treated with bronchodilators. Forty-six % of the patients had concurrent congestive heart failure exacerbation and received furosemide for diuresis; 80% of the patients received steroids and antibiotics. EPAP ranged from 5 to 8 cm H2O. IPAP ranged from 8 to 20 cm H2O. BMI correlated with both IPAP (r = 0.4826, p=0.013) and EPAP (r = 0.7486, p<0.001). There was no correlation with BMI and the length of NIMV (r=0.1941, p=0.342). On multivariate linear regression analysis adjusted for both age and gender, the association between BMI and IPAP remained significant (p<0.01), but only marginally significant with EPAP (p=0.05).