Obstructive Lung Diseases: Airways 5 |

Microalbuminuria as a Cardiovascular Biomarker in Patients With COPD FREE TO VIEW

Srikant Agarwal, MD; Gopal Purohit, MD; Isha Garg, MD; Narendra Umashankar, MD
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Dr S.N. Medical College Jodhpur, Jodhpur, India

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):877A. doi:10.1016/j.chest.2016.08.977
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: To assess the prevalence and relationship of microalbuminuria (MAB) with clinical and physiological parameters in stable patients with COPD.

METHODS: 50 stable COPD patients were included. Detailed History was taken and Urine Albumin to Creatinine ratio(UACR) from Spot morning Urine Sample, Arterial blood gas analysis, Spirometry, BODE Index (body mass index,airflow obstruction,Mmrc grading of dyspnea,exercise performance by 6MWD) was performed. The presence of Microalbuminuria was defined as UACR being ≥ 20 mg/gm in men and ≥30 mg/gm in women.

RESULTS: Out of 50 patients, 13 (26%) had significant UACR. Pearson correlation analysis showed significant negative correlation between MAB and PaO2 ( p<.001). MAB was significantly associated with duration of illness (p=.042) as well as with arterial-alveolar oxygen difference (p<.001) .Using Multiple Linear regression MAB was only significantly associated with arterial-alveolar oxygen difference (A-aPO2) (p<.024).

CONCLUSIONS: Microalbuminuria is an early simple biomarker for asessing risk of cardiovascular disease and is related with hypoxemia found in COPD patients.

CLINICAL IMPLICATIONS: Microalbuminaria monitoring in COPD patients may be done for risk of cardiovascular morbidity or mortality. Also presence of Microalbumiuria in COPD could be a therapeutic target for Cardiovascular risk reduction as Statins are seen to reduce level of microalbuminaria.

DISCLOSURE: The following authors have nothing to disclose: Srikant Agarwal, Gopal Purohit, Isha Garg, Narendra Umashankar

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