Obstructive Lung Diseases: Airways 3 |

Relationship Between Resting Heart Rate and Exacerbation in Patients With COPD FREE TO VIEW

Ahmad Ismail, MBBCh; Aisya Natasya Musa, MBChB; Mohd Arif Mohd Zim, MBBCh; Mohd Ariff Fadzil, MBBS; Tengku Saifudin Tengku Ismail, MD
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Universiti Teknologi MARA, Malaysia, Batu Caves, Malaysia

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):855A. doi:10.1016/j.chest.2016.08.955
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: Resting heart rate is a readily available data and has been shown to be associated with mortality in COPD patients. However, there is a lack of data on whether it has any association with exacerbation. This study aims to identify the association between resting heart rate and exacerbation.

METHODS: This is a multi-centre cohort study with 12 months follow up of COPD patients recruited during acute exacerbation of COPD requiring hospitalisation from 1st April 2012 till 30th September 2015. Patient’s sociodemographic data, anthropometric indices and medications history were recorded at recruitment during acute exacerbation. Subjects were then followed up in clinic at 3 months after the recruitment (Month 0). The resting heart rate, spirometry and CAT score were collected at baseline. Subsequently, patient was seen in 2 clinic visits at Month 6 and Month 12 and followed up in between via telephone interview to collect data on exacerbation history.

RESULTS: A total of 147 patients were recruited in this study. The mean age of our patients was 66.76 ± 9.25 year. 76.9% of patients had higher resting heart rate (> 80 bpm). The mean resting heart rate was 86.91 ± 13.01 bpm. Patients with higher resting heart rate had significantly higher proportion of exacerbators compared to those with lower resting heart rate at month 3 (54.4% vs. 26.9%, p=0.013). The trend was followed through until Month 9. There were also statistically significant moderate strength linear correlation between resting heart rate and exacerbation frequency at month 3, month 6 and month 9 (r = 0.400, p < 0.001; r = 0.440, p < 0.001; and r = 0.416, p = 0.004). The mean exacerbation frequency was also significantly higher in the higher resting heart rate group at month 3 and month 6 (2.00 vs. 0.48, p<0.001; and 3.42 vs. 1.14, p = 0.004).

CONCLUSIONS: COPD patients with higher resting heart rate following exacerbation requiring hospitalisation demonstrated increased risk of exacerbation, with higher exacerbation frequency seen at 3, 6 and 9 months of follow up.

CLINICAL IMPLICATIONS: Knowing the resting heart of patients may predict whether they are at risk of having an exacerbation up to 9 months after an episode of exacerbation.

DISCLOSURE: The following authors have nothing to disclose: Ahmad Ismail, Aisya Natasya Musa, Mohd Arif Mohd Zim, Mohd Ariff Fadzil, Tengku Saifudin Tengku Ismail

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