Obstructive Lung Diseases: Airways 3 |

Radiologic Characterizations in Emphysema and Its Influence on Bode Index FREE TO VIEW

Sudhir Agarwal, MD; Avinash Jain, MBBS
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Institute of Medical Sciences, Varanasi, India

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):848A. doi:10.1016/j.chest.2016.08.948
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: The purpose of the study was to see relationship between QHRCT-defined emphysema along with airway abnormalities and BODE index. BODE a multidimensional scoring system comprised of Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index

METHODS: Ninety-two COPD patients meeting Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria for COPD with QHRCT analysis were included in the present study. The density mask technique was used to measure the total lung emphysema. Mean wall thickness (WT) and wall area percentage (WA%) in segmental bronchi was estimated by visual semi-automated programme analyses. Influence of emphysema severity and airway abnormality on BODE was compared by multivariate modeling.

RESULTS: Data from 92 patients was available for final analysis. The majority(63.2%) of these patients were ex-smokers and 56% had moderate COPD. Emphysema percentage was correlated with total BODE score. There was 1.22 fold increase in standard deviation when emphysema percentage was correlated with BODE which was statistically significant ( p <0.001). Visual semi-automated programme analysis showed statistically significant increase in mean wall thickness and wall area percentage.

CONCLUSIONS: Emphysema and airway disease both relate to clinically important parameters. Emphysema is a stronger predictor of BODE and its systemic components MMRC, 6MWT, and BMI than airway abnormalities.

CLINICAL IMPLICATIONS: COPD phenotyping by Quantitative HRCT (QHRCT) provide unique information of clinical outcome and there is definite correlation between radiological characterizations in COPD with BODE Index.

DISCLOSURE: The following authors have nothing to disclose: Sudhir Agarwal, Avinash Jain

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