RESULTS: Overall, 9716 patients were included (median follow-up 4.90 years). The mean age was 47.09 years, and 62.5% were female. An average 68.11 physician visits, 20.00 specialist visits, 5.14 emergency room visits, and 2.90 hospitalizations were reported per 100 person-years. Average adjusted DHC of a severe asthmatic was approximately $1,900 CAD/year, with non-adherent patients costing more per year than adherent patients ($1,937 vs. $1,596, P<0.001). ), Patients experiencing ≥2 exacerbations/year reported adjusted DHCs more than 5 times that of the overall cohort ($10,384).