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Lung Pathology: Student/Resident Case Report Poster - Lung Pathology I |

Macrolide Anti-Inflammatory Therapy in Secondary Organizing Pneumonia: A Case Series

Hermann Simo, MD; Arjan Flora, MD; Ragheb Assaly, MD
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University of Toledo Medical Center, Toledo, OH


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):799A. doi:10.1016/j.chest.2016.08.895
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SESSION TITLE: Student/Resident Case Report Poster - Lung Pathology I

SESSION TYPE: Student/Resident Case Report Poster

PRESENTED ON: Tuesday, October 25, 2016 at 01:30 PM - 02:30 PM

INTRODUCTION: Organizing pneumonia (OP) is a diffuse interstitial lung disease with histopathologic proliferation of granulation tissue extending from the alveoli and alveolar ducts to the bronchioles due to alveolar epithelial injury. The inflammatory response of idiopathic or known secondary causes result in the leakage of plasma proteins leading to fibroblast recruitment and fibrin formation. Although there have been no randomized controlled trials, corticosteroid therapy has been the mainstay therapy for persistent and progressive disease. Over the last several years, several case reports and case series have shown that the immunomodulatory properties of macrolide antibiotics provide an alternative to long term corticosteroids in mild, stable disease or as an adjuvant therapy in persistent and progressive disease.

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