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Lung Pathology: Lung Pathology |

Serum Amyloid a Immunostaining of Granulomatous Tissue as a Novel Diagnostic Test for Sarcoidosis

Efstratios Koutroumpakis, MD; Albert Huho, MD; Siddhartha Dalvi, MD; Timothy Jennings, MD; Amit Chopra, MD; Aakash Modi, MD; Neha Rane, MD; David Prezant, MD; Christine Sheehan, MD; Mehul Patel, MD; Llewellyn Foulke, MD; Marc Judson, MD
Author and Funding Information

Albany Medical Center, Albany, NY


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):788A. doi:10.1016/j.chest.2016.08.884
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SESSION TITLE: Lung Pathology

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: To determine the sensitivity and specificity of Serum Amyloid A (SAA) staining in diagnosing sarcoidosis.

METHODS: Histological specimens from patients with granulomatous diseases were retrospectively identified from January 2004 to December 2013. Medical records were reviewed to ensure that a specific granulomatous diagnosis could be determined. SAA staining was performed using standardized algorithms on an initial group of 5 sarcoidosis and 5 non-sarcoidosis histological specimens. The SAA stain was modified to maximize specificity for the diagnosis of sarcoidosis. The modified SAA immunostaining technique was subsequently used to stain the remaining specimens. Two pathologists independently reviewed the specimens, while remaining blinded to the diagnosis. Specimens with conflicting reads were reevaluated blindly by the two pathologists simultaneously and a consensus decision was reached.

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