DISCUSSION: Acute Fibrinous and Organizing Pneumonia is a rare interstitial pneumonia pattern characterized by intra-alveolar fibrin deposition. Beasly et al first described it in 2002 as an unusual type of acute lung injury. In 2009, the first case of AFOP following HSCT was reported; unfortunately that patient did not survive. We report a case, appearing to be the first per our literature search, of successfully treated AFOP following HSCT. At the present time, no specific treatment exists, but patients may benefit from corticosteroid therapy, as appeared to happen in our case.