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Lung Cancer: Lung Cancer II |

A Microsatellite Instability Analysis Using the Promega Panel in Lung Adenocarcinoma

Kazuya Takamochi, MD; Fumiyuki Takahashi, MD; Yoshiyuki Suehara, MD; Shigehisa Kitano, MD; Eiichi Sato; Shinji Kohsaka; Kenji Suzuki, MD
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Juntendo University School of Medicine, Tokyo, Japan


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):715A. doi:10.1016/j.chest.2016.08.810
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SESSION TITLE: Lung Cancer II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: DNA mismatch repair (MMR) deficiency has recently received increasing attention as a significant biomarker to predict the treatment effect of immune checkpoint inhibitors for various malignant neoplasms. The MMR status can be evaluated by an analysis of microsatellite instability (MSI). The frequency of MSI in non-small cell lung cancers varies considerably in previous reports, ranging from 2-30%. It is difficult to compare these studies because the number of loci analyzed and their locations differ. In the present study, we analyzed MSI for lung adenocarcinomas using the Promega panel, which is the latest and the most reliable diagnostic test for Lynch syndrome.

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