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Lung Cancer: Lung Cancer II |

Microrna-144 Expression Overcomes Resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR Mutant Lung Cancer Cells by Targeting Survivin

Ki Eun Hwang, MD; Eun-Taik Jeong, MD; Hak-Ryul Kim, MD
Author and Funding Information

Wonkwang University Hospital, Iksan city, Korea (the Republic of)


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):714A. doi:10.1016/j.chest.2016.08.809
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SESSION TITLE: Lung Cancer II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: The emergence of drug resistance in cancer patients limits the success rate of clinical chemotherapy. MicroRNAs may play a role in chemoresistance and may be involved in modulating some drug resistance-related pathways in cancer cells. In this study, we hypothesized that microRNA-survivin interaction was involved in resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) cells. We focused on the effect of altered expression of microRNAs on EGFR-TKI resistance in EGFR-TKI-resistant cell lines.

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