SESSION TITLE: Lung Cancer II
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM
PURPOSE: The emergence of drug resistance in cancer patients limits the success rate of clinical chemotherapy. MicroRNAs may play a role in chemoresistance and may be involved in modulating some drug resistance-related pathways in cancer cells. In this study, we hypothesized that microRNA-survivin interaction was involved in resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) cells. We focused on the effect of altered expression of microRNAs on EGFR-TKI resistance in EGFR-TKI-resistant cell lines.