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Lung Cancer: Lung Cancer I |

Predictive Value of Preoperative Serum Tumor Marker Levels for Pathological Characteristics of Resected Lung Adenocarcinoma

Terumoto Koike, MD; Akihiko Kitahara, MD; Seijiro Sato, MD; Takehisa Hashimoto, MD; Shin-ichi Toyabe, MD; Masanori Tsuchida, MD
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Niigata University, Niigata, Japan


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):699A. doi:10.1016/j.chest.2016.08.794
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SESSION TITLE: Lung Cancer I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: The aim of this study was to investigate the association between preoperative serum tumor marker levels and pathological characteristics of resected lung adenocarcinoma.

METHODS: We retrospectively reviewed patients with lung adenocarcinoma who had undergone macroscopic complete resection from 2013 to 2015. Patients with multiple lung cancer other than adenocarcinoma, previous treatment history of lung cancer, or active other malignancies were excluded. Preoperative serum tumor marker levels (CEA, SCC, SLX, CYFRA, ProGRP, and NSE) and preoperative clinical factors (age, sex, smoking index, and tumor size) were analyzed with univariate analysis (Fisher’s exact test or the chi-square test) and multivariate logistic regression analysis to identify predictors for the pathological involvement (positive pleural effusion or lavage cytology, pleural involvement, pulmonary metastasis, lymph node involvement, lymphovascular involvement, and/or upstaging) or the poor prognostic subtypes (solid or micropapillary predominant adenocarcinoma). For the significant factors, optimal cutoff points were determined with a receiver operating characteristic (ROC) analysis.

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