INTRODUCTION: FDG (fluorodeoxyglucose) PET-CT is an important modality for characterizing, staging and restaging of esophageal cancer. FDG as an analog of glucose is a nonspecific agent for tumor imaging. A focal esophageal FDG uptake on PET should bring up the differential diagnosis of esophageal cancer, metastatic disease, infection and inflammation. The presence of lymphadenopathy follows the drainage pathway of esophageal cancer could be helpful. However, an infectious process may have similar appearance. The definite diagnosis relies on tissue biopsy.