METHODS: We conducted a quality improvement project at the Memorial Hermann hospital (MHH) transplant surgical ICU (TSICU) from July 2014 to June 2015 following the Six Sigma D-M-A-I-C (Define-Measure-Analyze-Improve-Control) format. All intubated patients on mechanical ventilation admitted to the TSICU requiring more than 1 day stay were included in the study. Baseline qualitative and quantitative data were collected for a 3 month period. Subsequent interventions included: education and training of staff on mobility, reducing practices that hinder mobility (over sedation), education and involvement of patient’s families, and consultation of physical therapy (PT). A control phase will sustain the changes made by introducing controls for these changes and monitoring them by regular data collection and evaluation. Outcomes were measured to determine improved process measures such as frequency/duration/grade/type of mobility, in addition to RASS score, days sedated, and initiation of PT consultation.