RESULTS: A weighted sample of 126,825 (0.35 %) admissions for MPE was identified among the 36,484,846 weighted admissions included in the database. Of these patients, 70,750 (55.8 %) were female, and 88,150 (69.5 %) were Caucasian. The median, interquartile range (IQR) age at admission was 68.0 (58.4-77.2). MPE was more commonly diagnosed in patients with Medicare insurance and in the lower income quartile. Lung (37.8%), breast (15.2%), hematologic (11.2%), GI tract (11.0%), and gynecologic (9.0%) cancers were the most common primary malignancies associated with MPE. The median (IQR) LOS was 5.5 (2.7-10.1) days. The inpatient mortality rate was 11.6%. Median (IQR) hospitalization total charges was $42,376 (21,618-84,679). In the multivariate analyses, sex, location of patient’s residence, primary insurer, primary types of malignancies, and presence of comorbidities were independent predictors of inpatient mortality.