Diffuse Lung Disease: Connective Tissue-Associated Interstitial Lung Disease |

Correlation of PFT Parameters With HRCT-Fibrosis Score in Scleroderma Patients FREE TO VIEW

Vanessa Yap, MD; Massa Zantah, MD; Pardeep Athwal, MD; Electra Kaloudis, MD; Debapriya Datta, MD; Raymond Foley, MD
Author and Funding Information

University of Connecticut Health Center, Farmington, CT

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;150(4_S):476A. doi:10.1016/j.chest.2016.08.490
Text Size: A A A
Published online

SESSION TITLE: Connective Tissue-Associated Interstitial Lung Disease

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: A recent study reported that pulmonary function tests (PFTs) have high false negative rates for identification of scleroderma patients with significant interstitial lung disease (ILD) on high resolution CT (HRCT) of chest. A normal FVC was reported in 62.5% of these scleroderma-ILD patients. The objective of this study was to determine the correlation between PFT parameters (Forced Vital capacity [FVC], Total Lung capacity [TLC] and Diffusion Capacity [DLCO]) with the extent of ILD measured by a fibrosis score on HRCT of chest in patients with scleroderma.

METHODS: We reviewed the records of 74 patients with scleroderma without pulmonary arterial hypertension followed at our institution. Patient demographics and PFT parameters (FVC, TLC, and DLCO) were noted. Patients’ chest HRCT scans were graded by a radiologist for ILD by a HRCT fibrosis score, calculated by estimating the percentage of parenchymal involvement in three zones (upper, middle, lower) of each lung, with a score of 100 representing normal and a score of 400 representing severe fibrosis. PFT variables were recorded as percent predicted (%) and expressed as mean ± SD. Pearson’s test for linear correlation was used to determine correlation of fibrosis score with FVC, TLC and DLCO.

RESULTS: Mean age was 57.4 ± 12.7 years; 66% were females; 76% had limited disease. Mean FVC was 87.2 ± 23.3%; mean TLC was 93.8 ± 15.7%; mean DLCO was 73.5 ± 21%. Normal FVC was seen in 39%; normal TLC in 46%; normal DLCO in 13%. Mean fibrosis score was 109 ± 27 (Range: 100-280). Using Pearson’s correlation analysis, correlation between FVC/TLC/DLCO and fibrosis-score were as follows: Fibrosis Score vs. FVC: r = -0.313; p=0.04;Fibrosis Score vs. TLC: r = -0.559; p<0.001;Fibrosis Score vs. DLCO: r = -0.38; p=0.01.

CONCLUSIONS: Majority of patients with scleroderma, including the limited type, have abnormal PFTs. Abnormality in DLCO was more common than abnormality in FVC and TLC. ILD estimated by the fibrosis score correlated significantly with FVC, TLC and DLCO.

CLINICAL IMPLICATIONS: ILD does not seem to be a major co-morbidity in patients with limited scleroderma. Results need to be validated in larger groups.

DISCLOSURE: The following authors have nothing to disclose: Vanessa Yap, Massa Zantah, Pardeep Athwal, Electra Kaloudis, Debapriya Datta, Raymond Foley

No Product/Research Disclosure Information




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543