CASE PRESENTATION: A forty-seven year old female current smoker with a history of asthma presented with five days of progressive fatigue, shortness of breath, cough, sore throat, and loss of voice and was found to be tachycardic, tachypneic, diaphoretic on arrival to the hospital. Investigations demonstrated Influenza B with multifocal opacities consistent with infection on chest CT and mild respiratory acidosis on arterial blood gas with no other abnormalities. She experienced worsening shortness of breath and tachypnea with normal oxygen saturations despite treatment with oseltamivir, levofloxacin, benzonatate capsules, nebulizers, supplemental oxygen, lorazepam, morphine, racemic epinephrine, and methylprednisolone. Otolaryngology (ENT) performed a beside laryngoscopy which revealed 80% subglottic obstruction due to copious secretions and sloughing of tissue. Following this procedure, the patient precipitously desaturated to the 70s and an emergent tracheostomy was performed along with flexible bronchoscopy showing findings consistent with Pseudomembranous tracheobronchitis (PMTB). Bronchoalveolar lavage was positive for methicillin resistant Staphylococcus aureus (MRSA) as well as Influenza B with subsequent blood cultures also growing MRSA. For the remainder of her hospitalization, antibiotics were deescalated to intravenous (IV) vancomycin, oral vancomycin for Clostridium difficile infection (CDI), and five days of oseltamivir. She was weaned off mechanical ventilation. Repeat bronchoscopies showed slight improvement in the severity of PMTB. She was discharged to complete her courses of IV and oral vancomycin for MRSA bacteremia and CDI, respectively, with follow up with ENT and Pulmonology.