DISCUSSION: Reinke’s edema, commonly seen in female gender, often presents with hoarseness and gradual deepening of voice. Risk factors include smoking, gastro-esophageal reflux disease and vocal cord abuse. It can cause inspiratory stridor in severe cases and can complicate airway management causing difficulties with intubation or extubation. Reinke’s edema may explain why even minimal laryngeal edema can cause clinically significant airway obstruction in some patients. Treatment for Reinke’s edema involves elimination of risk factors and if this fails, surgery may be required in rare cases. In the event of difficult airway management and presence of risk factors for Reinke’s edema, an otolaryngology consultation and CT scan of the neck should be undertaken.