CASE PRESENTATION: A woman in her sixties, with a medical history of pacemaker for complete heart block, seizure disorder, and poorly controlled Type I Diabetes complicated by limb amputation, presented after two seizures. Seizures were attributed to underlying sepsis as imaging showed gas gangrene of her right first toe. Blood cultures drawn during admission grew Corynebacterium striatum. Blood cultures were considered contaminated, as repeat cultures had no growth after she completed her antibiotic course. Patient presented months later with shortness of breath and was admitted for acute heart failure exacerbation. Blood cultures drawn from this admission also grew Corynebacterium striatum along with a positive urine culture. Patient received antibiotics and the blood culture was again considered a contaminant. Routine echocardiogram showed moderate mitral valve regurgitation (MVR) and no documented vegetations. Patient was discharged home with oral antibiotics. Patient presented two weeks later for lethargy and was admitted for an infected foot ulcer. Blood cultures drawn on admission re-demonstrated Corynebacterium striatum. Repeat echocardiogram showed severe worsening MVR with a mobile echodensity. A trans-esophageal echocardiogram was performed, which confirmed a large echodensity, likely representing a vegetation. An infectious disease specialist confirmed the diagnosis of endocarditis and recommended continuing IV antibiotics for six weeks. However, the patient’s family opted for palliative care and patient expired.