RESULTS: Among the 248 patients (mean age, 64.9 ± 18 years; 51% men), there was 23% mortality in the ICU. Baseline demographics were similar between survivors and deceased patients. Multivariate analysis revealed the following three independent predictors of ICU mortality: ratio of mitral E wave to early diastolic velocity of medial mitral annulus (E/e’) (OR: 1.04, 95% CI: 1.0-1.08, p<0.05), APACHE II score (OR: 1.07, 95% CI: 1.0-1.1, p<0.05) and lactate levels (OR: 1.37, 95% CI: 1.2-1.6, p<0.05). 32% had normal diastolic function, 47% had grade I dysfunction and 19% had grade II dysfunction. There was an incremental increase in ICU mortality with higher grades of diastolic dysfunction; however, this trend did not reach significance (p=0.36). Compared to pre-SS, TTEs during SS demonstrated significantly higher E/e’ medial annulus (16.15 ± 12.44 and 21.04 ± 16.35; p = 0.048). There were no other statistically significant differences in diastolic dysfunction parameters.