RESULTS: The severity of illness, assessed by APACHE II scores, was similar between the OBESE group (26.6, n=54) and NON-OBESE group (24.7, n=96). There were no differences in ICU LOS (12 days vs 10.5 days, p-value=0.29), hospital LOS (15.3 days vs 16.2 days, p-value=0.68), ventilator-days (8.9 days vs 7.0 days, p-value=0.15) and total hours on DEX infusion (44 hours vs 40 hours, p-value=0.56) among the OBESE AND NON-OBESE groups. There was a low incidence of bradycardia (22%) in OBESE group compared to NON-OBESE group (39%) which was statistically significant (p-value=0.03). The average dose at which the bradycardia occurred in both the groups was 0.7 mcg/kg/hr. The incidence of hypotension (OBESE 40% vs NONOBESE 35%, p-value=0.59) was similar between the two groups. Mortality in the OBESE group was 15%(n=8) compared to 7%(n=7) in the NON-OBESE group.