METHODS: Medical records of all patients who had a platelet count > 600k/mm3 during their hospitalization at Westchester Medical Center from 8/1/15 to 1/31/16 were reviewed. Patients who had any oncological diagnosis or a platelet count > 600k/mm3 at the time of admission were excluded. To ensure exposure to a major stressor and to more accurately assess the onset of the stress, only patients admitted to an intensive care unit (ICU) were included. The onset of the major stressor (major trauma, burns, emergency surgery, septic shock, respiratory failure, etc.) was determined by a reviewer while being blinded to the date of the maximal platelet count.