PURPOSE: Respiratory failure is the most common reason for ICU readmission. While multifactorial etiologies contribute, the final common pathway leading to respiratory decompensation often escapes early recognition due to generally insufficient respiratory monitoring in non-intubated patients. Current clinical practice relies on intermittent measurement of respiratory rate, subjective clinical assessment, and secondary indicators of respiratory status, like EtCO2 and SpO2. As a result, patients often spend extra time in the ICU as a precaution, and despite current practice recommendations for early extubation, clinicians often err of the side of caution and keep patients intubated longer than necessary. Clinicians often use quantitative measures like the rapid shallow breathing index (RSBI) in intubated patients as a predictor of patient-readiness for ventilator weaning and extubation. Here we evaluate the ability of a non-invasive Respiratory Volume Monitor (RVM) that provides quantitative measurements of minute ventilation (MV), tidal volume (TV) & respiratory rate (RR) for non-intubated patients to evaluate patients’ respiratory status, including RSBI pre- and post-extubation. We propose that RSBI may be useful in non-intubated patients when making decisions regarding reintubation or the implementation of non-invasive ventilation (NIV).