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Critical Care: Heme and infection ICU |

Fibrin Clot Formation Kinetics in Trauma Patients

Johana Gomez Builes, MD; Sandro Rizoli, PhD; Amanda McFarlan, RN; Michelle Sholzberg, MD; Andrea Petropolis, MD; Amer Zwein; Airton Leonardo Manoel, MD
Author and Funding Information

St Michael's Hospital, Toronto, ON, Canada


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):285A. doi:10.1016/j.chest.2016.08.298
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SESSION TITLE: Heme and infection ICU

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, October 23, 2016 at 07:30 AM - 08:30 AM

PURPOSE: The development of acute traumatic coagulopathy is associated with increased mortality. Thrombin generation (TG) is pivotal for an effective hemostatic response. Tests for assessing TG are laborious, costly, and unsuitable for emergency settings. Alternatively, thromboelastometry (TEM), a point of care test, assess the clot formation dynamics and its strength. Also, provides a profile of the speed of clot growth from initiation to reach the maximum velocity. Recent studies have shown a strong correlation between TEM fibrin clot waveform analysis and TG curves, suggesting that TEM may indirectly measure TG kinetics. The objective of the study is to describe the velocity profile of clot formation (TG) assessed by TEM in adult trauma patients and explore whether they are associated with the severity of the trauma and clinical outcomes such as blood transfusion (a surrogate for shock) and mortality.

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