CASE PRESENTATION: Case 1: A 18 yr old young male was admitted to emergency room with agitation, confusion and high fever. His relatives mentioned that he was using bonsai for last week. On admission, blood pressure:125/75 mmHg, RR: 25/min, body temperature: 39 °C, PR: 100/min and Glasgow Coma Scale:9. On physicial exam crackles were heard bilaterlly. Chest x-ray was showing infiltrates on both lower zones. Routine laboratory results were normal except for elevated CRP: 118 mg/L. Blood gases revealed pH:7.22 pCO2: 69.8 mmHg pO2:66.9 HCO3:21.8 mmol/L SO2: 89.8% consistant with respiratory acidosis. On 5th day of treatment, chest x-ray has turned to normal. Case 2: A 21 yr old young male was admitted to emergency room with loss of consciousness. On admission, blood pressure: 140/90 mmHg, RR: 35/min, body temperature: 36.1 °C PR: 115/min and Glasgow Coma Scale:10. Physicial exam demontrated rales on right hemithorax. He was using syntetic cannabinoids for a while. On chest x-ray, heterogenous infiltrates was seen on right middle and lower zones. Blood gases showed pH:7.36 pCO2: 33.7 mmHg pO2:63.6 HCO3:19.5 mmol/L SO2: 93.7%. On 3rd day of treatment, chest x-ray has turned to near-normal (Image).