CASE PRESENTATION: As of the end of 2014 the new comers were subjected to a chest X-ray screening, according to the provisions the regional health authorities. Underwent chest X-ray 257 subjects with mean age of 25,9 years (range 16-48 years) received in our territory between October 2014 and January 2016. The 95,3% are male, 18.3% coming from Asia (Pakistan, Afghanistan, Bangladesh), while 81,7% from sub-Saharan Africa (o, which 79,4% from the countries bordering the Gulf of Guinea and the remaining 2,3% from the Africa's Horn). We founded 53 altered radiograms: 12 suggesting basal pleural consolidated outcomes, 21 with apical pleural thickening, 5 with basal inflammatory thickening, 1 with pulmonary excavated condensation of the upper left lobe that was later diagnosed as pulmonary tuberculosis M. tuberculosis positive; the remaining X-rays showed no abnormalities consistent with TB disease. The epidemiological survey conducted on confirmed case of pulmonary tuberculosis highlighted nine close contacts (that came from the same country and lived in the same reception center) who underwent immunological diagnostic TIGRA with Quantiferon TB Gold method. All subjects were positive with values between 0.55 and 9.54 (cut off 0.55), but the respective thoracic radiograms showed no signs of disease. The 9 subjects were diagnosed as latent TB and subjected to anti-tuberculosis prophylaxis with isoniazid 300 mg daily for six months. They were also subjected to immunoassay all other subjects with radiological abnormalities consistent with TB and none of them tested positive. The patient suffering from pulmonary tuberculosis was subjected to specific treatment for six months with isoniazid 300 mg daily, pyrazinamide 500 mg 3 times a day, rifampicin 450 mg twice a day; during the first two months was also administered ethambutol 400 mg three times a day. The patient has completed treatment and he is currently free from the disease in a five months follow-up.