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Critical Care: Global Case Report Poster - Miscellaneous |

Successful Treatment of Steroid-Resistant Fibrosing Organising Pneumonia Causing Respiratory Failure With Mycophenolic Acid

Christina Paul, MBChB; Ammy Lin-Shaw, BScPharm; Mariamma Joseph, MBBS; Keith Kwan, MD; Gianluigi Sergiacomi, MD; Marco Mura, MD
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Western University, London, ON, Canada


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):277A. doi:10.1016/j.chest.2016.08.290
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SESSION TITLE: Global Case Report Poster - Miscellaneous

SESSION TYPE: Global Case Report Poster

PRESENTED ON: Tuesday, October 25, 2016 at 01:30 PM - 02:30 PM

INTRODUCTION: Organizing pneumonia (OP) is a well defined pathologic-clinical entity characterized by intra-alveolar accumulation of granulation tissue (1). The term “cryptogenic” is used when no aetiology is identified. The main treatment of OP is corticosteroids (CS), with generally rapid response, complete resolution of pulmonary infiltrates and normalization of lung function. However treatment of more aggressive, fibrosing forms of OP is not standardized. Mycophenolic acid (MPA) is the active component of mycophenolate mofetil, a reversible inhibitor of inosine-5′-monophosphate dehydrogenase. MPA is increasingly used as steroid sparing agent for interstitial lung disease (ILD) (2). We present a case series of biopsy-proven fibrosing OP leading to severe respiratory failure, with only partial response to CS, but significant improvement after treatment with MPA.

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