RESULTS: 150 patients on DEX infusion in the ICU were studied. The severity of illness, assessed by APACHE II scores, was similar amongst the SUBS group (25.6, n=90) and NONSUBS group (25.1, n=60). The SUBS group had statistically significant shorter ICU length of stay (LOS) (8.5 days vs 15 days, p< 0.0001), ventilator days (5.6 days vs 10.8 days, p< 0.0001) and hospital LOS (13 days vs 20 days, p = 0.0020). The difference in the mean hours of infusions for SUBS group (38 hours) and NONSUB (47 hours) did not reach statistical significance (p = 0.16). The incidence of bradycardia (SUBS 31% vs NONSUBS 36%, p = 0.48) and hypotension (SUBS 32% vs NONSUBS 45%, p = 0.12) were similar among the two groups. Mortality in the SUBS group was 4% compared to 18% in the NONSUBS group.