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Chest Infections: Tuberculosis |

Clinical Implications of Diabetes Mellitus in Adults With TB: Risk for Poor Outcomes and Mortality

Leila Barss, MD; Evan Orlikow, MD; Sen Phang, MD; Natasha Sabur, MD; Michael Arget; Julie Jarand, MD; Stephen Field, MD; Martha Ainslie, MD; Dina Fisher, MD
Author and Funding Information

University of Calgary, Calgary, AB, Canada


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;150(4_S):206A. doi:10.1016/j.chest.2016.08.215
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SESSION TITLE: Tuberculosis

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM

PURPOSE: To evaluate the association between incident and prevalent diabetes mellitus (DM) and clinical presentation, treatment failure, and mortality in adults with active tuberculosis (TB) in Canada.

METHODS: A retrospective chart review of all adult patients treated for TB in two large Canadian cities (Calgary, AB and Winnipeg, MB) between 2007-2012 was performed. The primary outcome was all cause mortality during TB treatment. Patients aged ≥18 years with a clinical or microbiologic diagnosis of mycobacterium tuberculosis (pulmonary and/or extrapulmonary) with adequate chart data were included. Determination of DM prevalence at time of TB diagnosis was based on chart diagnosis of DM or documented use of insulin or oral hypoglycemics. An incident diagnosis of DM was defined as new diagnosis within six months of TB diagnosis. Secondary outcomes included: treatment failure (death, relapse, or culture positivity at 4 months), presence of cavitary disease, smear and culture positivity, and presence of drug resistance. Unadjusted odds ratios were used to estimate the association between DM and mortality and treatment failure.

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