SESSION TITLE: Tuberculosis
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Wednesday, October 26, 2016 at 01:30 PM - 02:30 PM
PURPOSE: To evaluate the association between incident and prevalent diabetes mellitus (DM) and clinical presentation, treatment failure, and mortality in adults with active tuberculosis (TB) in Canada.
METHODS: A retrospective chart review of all adult patients treated for TB in two large Canadian cities (Calgary, AB and Winnipeg, MB) between 2007-2012 was performed. The primary outcome was all cause mortality during TB treatment. Patients aged ≥18 years with a clinical or microbiologic diagnosis of mycobacterium tuberculosis (pulmonary and/or extrapulmonary) with adequate chart data were included. Determination of DM prevalence at time of TB diagnosis was based on chart diagnosis of DM or documented use of insulin or oral hypoglycemics. An incident diagnosis of DM was defined as new diagnosis within six months of TB diagnosis. Secondary outcomes included: treatment failure (death, relapse, or culture positivity at 4 months), presence of cavitary disease, smear and culture positivity, and presence of drug resistance. Unadjusted odds ratios were used to estimate the association between DM and mortality and treatment failure.