CASE PRESENTATION: A 65-year-old woman presented with complaints of worsening dyspnea with associated dry cough and wheezing. Past medical history was notable for non-Hodgkin’s lymphoma on chemotherapy, end stage renal disease on hemodialysis, and tracheostomy tube placed during prolonged ICU course with multiple abdominal surgeries. There was no history of prior respiratory disease or tobacco abuse. Laryngoscopy revealed subglottic stenosis with greater than 50% airway occlusion. The patient was referred to us for endobronchial argon plasma coagulation (APC) treatments. Bronchoscopy revealed extensive polypoid lesions in the subglottic space (Fig. 1). Re-accumulation of tissue continued to cause severe subglottic stenosis despite serial APC treatments. Tissue specimens were collected for biopsy, and histopathology revealed polypoid granulation tissue and abundant fungal organisms morphologically consistent with Cryptococcus neoformans. Cryptococcal antigen testing was positive in serum (1:10 titer), but negative in CSF. Amphotericin B was given for two weeks in the hospital followed by three months of treatment with Fluconazole 200 mg daily. After completing antifungal therapy, repeat bronchoscopy showed complete resolution of the subglottic tissue overgrowth and tissue sampling confirmed clearance of infection (Fig. 2A). The patient remains on chronic suppressive therapy with Fluconazole 400 mg three times weekly after dialysis. Upon more recent re-evaluation, the patient had no further respiratory complaints, and with no tissue regrowth seen on bronchoscopy, the patient was successfully decannulated (Fig. 2B).