RESULTS: There were 2992 patients for analysis. Approximately 51% of patients were aged between 20-39 years, and 51.4% were male. Pulmonary disease alone occurred in 62.8% of patients, extrapulmonary TB occurred in 37%, while both pulmonary and extrapulmonary diseases occurred in 0.2%. New patients comprised 87% of cases. Patients treated by directly observed therapy at the start of therapy (n=2412) had a significantly higher cure rate compared with patients treated by self-administered therapy (n=580) (the sum of bacteriologic cure and completion of treatment, 85.8% versus 58.8%, p<0.0001). Among new smear-positive patients, treatment success was 88% DOT group vs 60.6% SAT group (81% vs 55% cure, 7% vs 5.7% completion); remaining outcomes were 4.3% vs 25.1% default, 2.2% vs 8% failure, 3% vs 3% death, and 2.6% vs 3.4% transfer. Rates of treatment failure, defaulted from treatment were significantly higher in SAT group compared with DOT group (3.3%, 33.6% versus 1.7%,7% respectively, p<0.03). The proportion of successful treatments differ significantly between the urban & rural patients under DOT and those under SAT (86.3%, 85.5% versus 73%, 49.8%, p<0.0001). In urban & rural patients under SAT there were (25.8% & 46.8 %) potentially unsatisfactory outcomes (treatment failure, defaulted from treatment, transfer out) compared with (10.5% & 11.5%) of those under DOT p<0.002).