RESULTS: An analysis of patient characteristics revealed no significant difference for weight, sex, race, history of angina, atrial fibrillation, and family history of CHF or COPD between readmitted and non readmitted. Patients who had a previous MI (22% vs 13%, p<0.0001), or diabetes (51% vs 46%, p=0.013) were significantly more likely to be readmitted. Patients with hypertension were less likely to be readmitted (29% vs 38%, p<0.0001). Patient weight was higher (186±63lbs vs 180±61lbs, p=0.0006) in those not re-admitted versus re-admitted. Emergency Department (ED) visits in the previous 12 months were increased in patients re-admitted (84.22% vs 74.28%, p<0.0001), as were total hospital admissions (76.01% vs 58.72, p<0.0001). At 96 hours and 48 hours before discharge, BUN, creatinine, serum osmolality, % neutrophils, WBC and anion gap were higher in re-admitted patients (P<.001 all). First 48 hours BUN/creatinine ratio was increased (20.0±10 vs 19.1±8.4, p=0.019) in readmitted patients; whereas first 48 hours of admission, 96 hours pre-discharge, and 48 hours pre-discharge, glomerular filtration rate and hemoglobin were reduced (p<0.0001 all).