METHODS: A retrospective review of patients undergoing diagnostic ENB was conducted. Between September 2012 and March 2016, 100 ENBs were performed in 95 patients for the evaluation of lung nodules. If a diagnosis was not achieved after ENB, a CT-guided biopsy or surgical resection was performed. Only patients with a confirmed non-small cell lung cancer (NSCLC) diagnosis were included in this analysis. Clinical factors, lesion location and size and presence of a bronchus sign were evaluated for their impact on achieving a successful diagnosis. Bivariate analysis was performed using two-sided chi-square tests.