RESULTS: Total 82 consecutive patients with severe asthma were recruited. Their mean postbronchodilator FEV1 was 69.2% predicted and FEV1/FVC was 67%. Twenty-one patients (28%) had serum total IgE ≥ 1,000 IU/L. A fumigatus sensitization was noted in 11 (52.3%) from 21 patients in high total IgE group (11 with positive sIgE for A fumigatus, 2 with positive SPT for aspergillus). Hence they were diagnosed ABPA. Six from 59 (10%) patients in low total IgE group had aspergillus sensitization (5 with positive SPT for aspergillus, 2 with positive sIgE for A fumigatus). Not only positive sIgE for A fumigatus but also positive sIgE for Dp1 or Dp2 was associated with having serum IgE level ≥ 1,000 IU/L (both with p = 0.005). However, positive SPT for different allergens were not different between low and high IgE group. Regarding patients in high total IgE group, age at onset of disease, lung function parameters, blood eosinophils and FENO were not different between patients with and without aspergillus sensitization. In patients with A fumigatus sensitization and high serum total IgE, HRCT detected central bronchiectasis was noted in 2 patients (ABPA-CB). Remaining 9 ABPA patients were labelled serologic ABPA (ABPA-S).