To investigate the risk of venous thromboembolism (VTE) among patients with sarcoidosis.
A cohort of 345 incident cases of sarcoidosis and 345 sex and age-matched comparator subjects in Olmsted County, Minnesota from 1976-2013 were identified from the comprehensive medical record-linkage system. Medical records were reviewed for deep venous thrombosis (DVT) and pulmonary embolism (PE). The cumulative incidence was estimated, adjusted for the competing risk of death. Cox proportional hazards models were used to compare the rate of development of these events between patients with sarcoidosis and the non-sarcoidosis comparison cohort.
The prevalence of VTE, DVT and PE prior to index date was not significantly different between cases and comparators. The risk of incident VTE adjusted for age, sex and calendar year was significantly higher among patients with sarcoidosis (HR 3.04; 95% CI, 1.47 – 6.29). Significantly elevated risk was observed in both subtypes of VTE with HR of 3.14 (95% CI, 1.32 – 7.48) for DVT and HR of 4.29 (95% CI, 1.21 – 15.23) for PE. A sensitivity analysis including only VTE events that occurred at least 6 months after the index date adjusted for age, sex and calendar year revealed somewhat lower HRs for VTE of 2.73 (95% CI, 1.30 – 5.72), for DVT of 3.00 (95% CI, 1.25 – 7.20) and for PE of 3.58 (95% CI, 0.98 – 13.03).
Increased risk of VTE among patients with sarcoidosis was observed in this population-based cohort.