0
Original Research |

Association of Sarcoidosis with Increased Risk of Venous Thromboembolism: A Population-Based Study 1976-2013

Patompong Ungprasert, MD; Cynthia S. Crowson, MS; Eric L. Matteson, MD, MPH
Author and Funding Information

Funding: This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676, and CTSA Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conflict of interest statement for all authors: We do not have any financial or non-financial potential conflicts of interest.

1Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA

2Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA

3Division of Epidemiology, Department of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA

Corresponding author: Division of Rheumatology, Mayo Clinic, 200 First Street SW Rochester, MN 55905, USA.


Copyright 2016, . All Rights Reserved.


Chest. 2016. doi:10.1016/j.chest.2016.09.009
Text Size: A A A
Published online

Abstract

Objective  To investigate the risk of venous thromboembolism (VTE) among patients with sarcoidosis.

Method  A cohort of 345 incident cases of sarcoidosis and 345 sex and age-matched comparator subjects in Olmsted County, Minnesota from 1976-2013 were identified from the comprehensive medical record-linkage system. Medical records were reviewed for deep venous thrombosis (DVT) and pulmonary embolism (PE). The cumulative incidence was estimated, adjusted for the competing risk of death. Cox proportional hazards models were used to compare the rate of development of these events between patients with sarcoidosis and the non-sarcoidosis comparison cohort.

Results  The prevalence of VTE, DVT and PE prior to index date was not significantly different between cases and comparators. The risk of incident VTE adjusted for age, sex and calendar year was significantly higher among patients with sarcoidosis (HR 3.04; 95% CI, 1.47 – 6.29). Significantly elevated risk was observed in both subtypes of VTE with HR of 3.14 (95% CI, 1.32 – 7.48) for DVT and HR of 4.29 (95% CI, 1.21 – 15.23) for PE. A sensitivity analysis including only VTE events that occurred at least 6 months after the index date adjusted for age, sex and calendar year revealed somewhat lower HRs for VTE of 2.73 (95% CI, 1.30 – 5.72), for DVT of 3.00 (95% CI, 1.25 – 7.20) and for PE of 3.58 (95% CI, 0.98 – 13.03).

Conclusion  Increased risk of VTE among patients with sarcoidosis was observed in this population-based cohort.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543